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Pineapple (ananas comosus) Extract Bromelain Monograph

The common Pineapple is anything but common. Apart from being a popular fruit it has wide use in the supplements industry and the source of the digestive enzyme Bromelain.

I use it regularly in my daily smoothies for the amazing flavour, but the bonus of all the added health benefits makes it a must have resident in your fridge. 

See below for some compelling evidence. 

Bromelain from PIneapple is available in these products:


Description
The pineapple (Ananas comosus) is a tropical plant with edible multiple fruit consisting of coalesced berries, also called pineapples, and the most economically significant plant in the Bromeliaceae family. (4) 


Traditional Uses
Chunks of pineapple are used in desserts such as fruit salad, as well as in some savory dishes, including pizza toppings and a grilled ring on a hamburger. Crushed pineapple is used in yogurt, jam, sweets, and ice cream. The juice of the pineapple is served as a beverage, and it is also the main ingredient in cocktails such as the piña colada. (4) 

Bromelain is considered as a food supplement and is freely available to the general public in health food stores and pharmacies in the USA and Europe. Existing evidence indicates that bromelain can be a promising candidate for the development of future oral enzyme therapies for oncology patients. Bromelain can be absorbed in human intestines without degradation and without losing its biological activity (5)


Active Constituents
The crude aqueous extract from stem and fruit of pineapple is known as bromelain. It is a mixture of different thiol endopeptidases and other components like phosphatases, glucosidase, peroxidases, cellulases, glycoproteins, carbohydrates, and several protease inhibitors (5)

Plant-based enzymes, such as bromelain from pineapple, serve as effective digestive aids in the breakdown of proteins. (6)

Clinical Studies

All the evidence in one comprehensive review suggest that Bromelain can be used as an effective health supplement to prevent cancer, diabetes, and various cardiovascular diseases in the long run. (5)

Bromelain is considerably absorbable in the body without losing its proteolytic activity and without producing any major side effects. Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics. It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death. (5) 

 

Digestive Support
Bromelain aids digestion by enhancing the effects of the digestive enzymes trypsin and pepsin. It can also help to prevent heartburn and ease diarrhea, if either are caused by a deficiency of digestive enzymes. Plant enzymes (such as papainbromelain, and ficin) have been extensively investigated as meat tenderizers. (7)


Anti-inflammatory
Bromelain is of interest to plastic surgeons because of its apparent ability to reduce pain, edema, inflammation, and platelet aggregation (1) 

Bromelain has analgesic properties which are thought to be the result of its direct influence on pain mediators such as bradykinin. The earliest reported studies investigating bromelain were a series of case reports on 28 patients, with moderate or severe rheumatoid or osteoarthritis. (5)

Pineapple
Anti-Thrombosis
Results suggested that bromelain could be used for treating acute thrombophlebitis, as it decreases aggregation of blood platelets, has a cardio-protective effect, ameliorates rejection-induced arterial wall remodelling, prevents thrombin-induced human platelet aggregation as well as reduces thrombus formation. (2)

Bromelain therapy leads to formation of platelets with increased resistance to aggregation and the combination of fibrinolytic and antithrombic properties appear to be effective. Two large scale tests on heart patients have shown a practically complete elimination of thrombosis. (3) 

Bromelain has been effective in the treatment of CVDs as it is an inhibitor of blood platelet aggregation, thus minimizing the risk of arterial thrombosis and embolism (5) 


Heart attack reduced
Bromelain prevents or minimizes the severity of angina pectoris and transient ischemic attack (TIA). It is useful in the prevention and treatment of thrombophlebitis. (5)

Cholesterol reduced
Bromelain may also break down cholesterol plaques and exerts a potent fibrinolytic activity. (5)

 

Conclusion

Pineapple smoothie anybody?



Bromelain from PIneapple is available in these products:

 

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References:

(1) Bromelain. Pubmed http://www.ncbi.nlm.nih.gov/pubmed/17102739

(2) A review of the use of bromelain in cardiovascular diseases. PubMed http://www.ncbi.nlm.nih.gov/pubmed/21749819 

(3) Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. PubMed http://www.ncbi.nlm.nih.gov/pubmed/6256612

(4) Pineapple, Wikipedia https://en.wikipedia.org/wiki/Pineapple

(5) Properties and Therapeutic Application of Bromelain: A Review PubMed http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/

(6) The role of enzyme supplementation in digestive disorders. PubMed http://www.ncbi.nlm.nih.gov/pubmed/19152478

(7) Exogenous proteases for meat tenderization. PubMed http://www.ncbi.nlm.nih.gov/pubmed/24499119

 

 

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